Skinterfaces Exploding Borders ââ“ Creating Membranes in Art Technology and Society

18th March 2020

I idea I should say something about the coronavirus for readers of this web log. I demand to state that the situation is fast moving, facts are irresolute, and I am not request anyone to go against whatsoever current medical communication.

Here, I am merely providing communication that I believe, currently, may exist of benefit to people out there. I am acutely aware that there is controversy swirling about, but I will not promote anything that tin cause any significant harm – simply may cause meaning good.

I have tended to wait dorsum a few years in fourth dimension for some bear witness, because electric current, emerging evidence is subject field to massive bias and controversy, with diverse vested interests getting involved. The 'older' prove has not been washed in a rush and is therefore more measured.

ane: Anti-inflammatories (NSAIDs)

COVID-19 appears to touch the lungs more than any other organ and COVID-nineteen can exist thought of equally a 'viral' community acquired pneumonia. There has been evidence for several years that anti-inflammatory agents eastward.g. ibuprofen, naproxen (NSAIDs) may worsen customs acquired pneumonia. As highlighted in this 2017 newspaper:

'Non-steroidal Anti-inflammatory Drugs may Worsen the Form of Community-Acquired Pneumonia: A Accomplice Study:

CONCLUSIONS:

Our findings advise that NSAIDs, often taken by young and good for you patients, may worsen the course of CAP with delayed therapy and a higher rate of pleuropulmonary complications.' ⁱ

There is now anecdotal evidence, particularly from French republic, that patients who take NSAIDs do considerably worse. Information technology has been suggested they may lead to an increased death rate.

Advice: Avert NSAIDs if possible

2: Vitamin C

Vitamins ever cause massive controversy, and the mainstream medical community tends to be highly critical of the use of vitamins. Notwithstanding, vitamin C has been constitute to have many, many, positive impacts on the immune arrangement. It also protects the endothelium lining claret vessels – thus preventing/delaying passage of pathogens from the bloodstream.

I include the full abstract from the 2017 newspaper 'Vitamin C and Immune Office.' It contains a bang-up deal of medical jargon, but I take highlighted the most important parts.

'Vitamin C contributes to allowed defense by supporting various cellular functions of both the innate and adaptive allowed arrangement. Vitamin C supports epithelial barrier function confronting pathogens and promotes the oxidant scavenging action of the skin, thereby potentially protecting against environmental oxidative stress.

Vitamin C accumulates in phagocytic cells, such as neutrophils, and tin can heighten chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing. Information technology is likewise needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage.

The role of vitamin C in lymphocytes is less clear, but it has been shown to heighten differentiation and proliferation of B- and T-cells, probable due to its gene regulating effects. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. In turn, infections significantly impact on vitamin C levels due to enhanced inflammation and metabolic requirements.

Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections. Condom prevention of infection requires dietary vitamin C intakes that provide at to the lowest degree adequate, if not saturating plasma levels (i.e., 100–200 mg/day), which optimize cell and tissue levels. In contrast, handling of established infections requires significantly college (gram) doses of the vitamin to compensate for the increased inflammatory response and metabolic demand.' ^two

In short, Vitamin C can assistance prevent respiratory infections. It can also help to treat established infections, although much higher doses are required. This seems to fit with emerging Chinese data which appears to be showing considerable success with high dose intravenous Vitamin C in treating coronavirus.

Information technology is unlikely that anyone working in the medical system in the West will concur to using high dose Vitamin C as role of any management programme. Still, if your loved i is extremely ill in hospital I would recommend speaking to the doctors and asking if this can be added.

Whilst information technology is possible that vitamin C may bear witness ineffective, it also does no harm. Those who are currently attacking the use of Vitamin C and attacking those who believe vitamin C may be beneficial are, I believe, mainly concerned with their personal reputations.

ADVICE: Take at least 2g of Vitamin daily C to 'forbid' infection, probably more like 5g. Increase the dose to at least 10g if yous are suffering symptoms.

3: ACE-inhibitors/ARBs

COVID-nineteen appears to enter the trunk using the ACE2 receptor (found on the surface of many cells, particularly in the lungs. Also found in loftier concentrations in the centre and kidneys.

Because of its affinity to ACE2 receptors (and the more widespread Renin Aldosterone Angiotensin Arrangement or "RAAS") COVID-19 is causing upset with the whole arrangement – in complex ways. The system itself is circuitous.

To remind those of a more than technical bent, here is the organisation:

I wished to brand it articulate that if COVID-19 touch on on the RAAS system, trying to work out the resultant abnormalities, is not easy.

At that place are two chief drugs that are designed to lower blood pressure past 'interfering' with the RAAS system. ACE-inhibitors (angiotensin converting enzyme inhibitors), and ARBs (angiotensin II receptor blockers). They are very widely prescribed.

Some people have suggested that these drugs should exist stopped. Others have suggested that they should exist continued. You may exist able to come across why the advice is contradictory, given all the possible interactions.

However, it does seem the COVID-19 creates hypokalaemia (a low blood potassium level). A ascension potassium level indicates recovery from the virus. This is probably due to interference with the hormone Aldosterone due to degradation of many ACE-receptors in the body.

ADVICE – currently non plenty information to provide any advice on ACE-inhibitors and ARBs. However, increased consumption of potassium, if symptomatic, can be brash. Dose?

'People who eat large amounts of fruits and vegetables tend to accept a high potassium intake of approximately 8000 to 11,000 mg/d,' ³

And then, up to Ig a day appears perfectly safe, and if more is being lost through the kidneys with COVD-19, there appears to be little danger of overdosage.

4: Chloroquine and Hydroxychloroquine

These drugs usually used to treat/forestall malaria (and are besides used to care for various 'allowed' illness). All the same, they have been found to exist effective in treating other viruses and seem to have been highly effective against COVID-19 ⁴. These drugs will only be available as part of medical management. They cannot be bought over the counter (in any country, as far as I know).

If you lot, or a loved i, is seriously sick, I would urge you lot to ask for – ane or the other – to be used. Hydroxychloroquine has fewer side furnishings (drug related adverse effects)

ADVICE – Inquire for one of these drugs if you, or a loved ane, is seriously ill with COVID-19.

5: Vitamin D

This 1 is uncomplicated. Vitamin D has important effects on the immune system ⁵. A depression vitamin D level in the winter is almost certainly why flu epidemics occur in the winter months. [Vitamin D is synthesized in the sun by the action of sunlight].

Advice – take at to the lowest degree 2000iu vitamin (preferably D3) daily.

I hope some people have constitute this useful. If annihilation I take written here proves to be incorrect, or unsafe, I will change it. Notwithstanding, I am working on the basis here of 'kickoff, do no harm.' The worse matter that any of this advice tin can practise, I believe, is to Non work.

1: https://www.ncbi.nlm.nih.gov/pubmed/28005149

ii: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/

3: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/485434

4: https://www.connexionfrance.com/French-news/French-researcher-in-Marseille-posts-successful-Covid-xix-coronavirus-drug-trial-results

5: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756814/

hendersondointow.blogspot.com

Source: https://drmalcolmkendrick.org/2020/03/18/coronavirus-covid-19/